What is the Origin of PSMA PET Scan?

PSMA was initially identified in the early 1990s, but the development of high-affinity radiolabeled ligands for PET imaging matured in the 2010s. The acronym combines the molecular target (PSMA) with the imaging modality (PET Scan). This technique represents a significant technological leap in the field of urological oncology, offering superior anatomical and functional detail compared to conventional imaging.

What is the Mechanism of PSMA PET Scan?

The mechanism involves the intravenous injection of a small molecule radiotracer, such as Gallium-68 or Fluorine-18 labeled PSMA-ligands, which circulate and selectively bind to the PSMA receptors on the cancer cell surface. The positron-emitting radionuclide then decays, emitting positrons that are detected by the PET scanner. The resulting data is reconstructed into a three-dimensional image, which visually maps the spatial distribution and metabolic activity of the PSMA-expressing cancer throughout the body.

PSMA PET Scan

Meaning

A PSMA PET Scan is an advanced molecular imaging technique utilizing Positron Emission Tomography (PET) to detect and stage prostate cancer with high sensitivity and specificity. The scan employs a radioactive tracer that specifically binds to Prostate-Specific Membrane Antigen (PSMA), a protein that is highly overexpressed on the surface of most prostate cancer cells, including metastatic lesions. This diagnostic tool allows clinicians to precisely locate primary tumors and identify distant metastases, even at very low levels of Prostate-Specific Antigen (PSA). The resulting images are critical for guiding therapeutic decisions, particularly in cases of biochemical recurrence.

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∞ PSMA PET Scan
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PSMA PET Scan

Meaning

Origin

Mechanism

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