What is the Origin of PSA Levels?

PSA was first identified and isolated in the 1970s and subsequently adopted as a clinical biomarker for prostate health. The term 'levels' refers to the quantitative measurement used in clinical laboratory testing. Its utility as a screening tool has been the subject of extensive clinical discussion.

What is the Mechanism of PSA Levels?

PSA functions as a serine protease, primarily responsible for liquefying the seminal fluid. Testosterone and its potent metabolite, dihydrotestosterone (DHT), regulate the production and secretion of PSA by the prostate epithelial cells. Therefore, fluctuations in androgen levels, as seen in male hormonal therapy, can directly influence the measured PSA concentration.

PSA Levels

Meaning

PSA Levels refer to the measured concentration of Prostate-Specific Antigen (PSA) in the blood, a glycoprotein enzyme produced primarily by the cells of the prostate gland. While a rise in PSA levels can indicate prostate cancer, it is also elevated in non-malignant conditions like benign prostatic hyperplasia (BPH) and prostatitis. Monitoring these levels is a standard component of male urological and hormonal health surveillance. It is a critical, though non-specific, biomarker of prostate status.

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