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Prothrombotic Factors

Meaning

Prothrombotic factors are a group of biochemical agents and physiological conditions that increase the risk of developing thrombosis, which is the formation of a blood clot within a blood vessel. These factors include specific clotting proteins, platelet aggregation markers, and conditions like hyperviscosity or endothelial dysfunction. In the context of hormonal health, clinicians must carefully assess these factors, as certain hormone replacement therapies can potentially modulate coagulation cascades. Understanding a patient’s baseline prothrombotic risk is critical for safe and personalized endocrine management, particularly when considering estrogen or testosterone administration.