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Proteostasis Network Optimization

Meaning

Proteostasis Network Optimization is a fundamental biological and longevity strategy focused on maintaining the integrity and balance of the proteome, which is the entire set of proteins expressed by an organism, cell, or tissue at a particular time. The proteostasis network encompasses the interconnected cellular processes of protein synthesis, folding, trafficking, and degradation, mediated by chaperones and the ubiquitin-proteasome system. Optimization aims to enhance the efficiency of this network to prevent the accumulation of misfolded or damaged proteins, which is a key hallmark of cellular aging and neurodegenerative disease. Maintaining this balance is essential for cellular resilience and long-term function.