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Proteostasis Network Enhancement

Meaning

Proteostasis Network Enhancement is a sophisticated clinical strategy focused on improving the cellular machinery responsible for maintaining protein homeostasis, which is the dynamic balance between protein synthesis, folding, trafficking, and degradation. This network, or proteostasis, is crucial because the functional integrity of all hormones, enzymes, and cellular structures depends on correctly folded proteins. Enhancement protocols aim to boost the capacity of quality control mechanisms, such as chaperone proteins and the ubiquitin-proteasome system, to prevent the accumulation of misfolded or damaged proteins that drive cellular senescence and neurodegeneration. Optimizing proteostasis is a core pillar of longevity medicine.