What is the Origin of Proteomic Clock?

This term is a recent development in geroscience and proteomics, following the establishment of the 'Epigenetic Clock' based on DNA methylation. The "Proteomic Clock" leverages the fact that protein levels and post-translational modifications reflect both genetic background and cumulative environmental and lifestyle influences. It is a powerful tool for precision longevity medicine.

What is the Mechanism of Proteomic Clock?

The clock's mechanism relies on the age-dependent changes in the expression of key regulatory and structural proteins involved in processes like inflammation, metabolism, and immune function. Specific protein markers are identified whose concentrations correlate strongly with chronological and functional age. By quantifying these protein signatures, the clock provides an integrated measure of the body's physiological state, reflecting the cumulative damage and repair efficiency over time.

Proteomic Clock ∞ Area

Proteomic Clock

Meaning

The Proteomic Clock is a novel biological aging measure that utilizes quantitative analysis of the human proteome—the entire set of proteins expressed by an organism—to estimate an individual’s biological age. This clock tracks age-related changes in the abundance and modification of specific proteins in the blood or tissues, providing a molecular readout of systemic senescence and health trajectory. It offers a sophisticated, functional assessment of aging beyond chronological years.