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Proteolytic Stability Extension

Meaning

Proteolytic Stability Extension is a biopharmaceutical strategy designed to significantly increase the resistance of a therapeutic peptide or protein, such as a recombinant hormone, to degradation by proteases, which are the enzymes that break down proteins within the body. This modification enhances the drug’s structural integrity, effectively protecting it from rapid enzymatic clearance in the bloodstream and tissues. The clinical result is a prolonged duration of action and a more consistent therapeutic effect, directly improving the pharmacokinetic profile and substantially reducing the required frequency of administration for the patient.