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Proteolytic Inactivation Resistance

Meaning

Proteolytic Inactivation Resistance refers to the biochemical characteristic of certain peptide-based therapeutic agents or endogenous hormones that makes them highly stable and resistant to degradation by proteolytic enzymes, particularly those found in the gastrointestinal tract and systemic circulation. This resistance is a crucial design feature for orally administered peptides, ensuring a sufficient concentration reaches systemic circulation to exert its therapeutic effect before being broken down. It is a measure of a molecule’s half-life and stability in vivo.