The continuous, dynamic process involving the simultaneous synthesis (anabolism) and degradation (catabolism) of proteins within the body’s tissues, particularly skeletal muscle. The kinetics refer to the rates at which these two opposing processes occur. A positive net turnover rate, where synthesis exceeds degradation, is essential for maintaining lean body mass, tissue repair, and overall metabolic health.
Origin
This fundamental concept is central to biochemistry and human physiology, describing the metabolic life cycle of proteins. The term “kinetics” is derived from the Greek kinēsis (movement), denoting the study of the rates of chemical processes.
Mechanism
Protein turnover is primarily regulated by the anabolic-catabolic hormone balance, with factors like Growth Hormone, IGF-1, and testosterone promoting synthesis, and cortisol promoting degradation. Amino acid availability and mechanical load also influence the rates. Clinical interventions target these hormonal and nutritional inputs to shift the net balance toward anabolism, thereby improving muscle mass and recovery.
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