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Protein Cross-Linking

Meaning

Protein Cross-Linking is a non-enzymatic post-translational modification process where adjacent protein molecules become chemically bonded to each other, often due to the reaction with reducing sugars, resulting in the formation of irreversible molecular aggregates. This process, a direct consequence of advanced glycation, stiffens tissues, impairs the function of long-lived structural proteins like collagen and elastin, and contributes significantly to the visible and systemic signs of aging. It is a critical factor in vascular and dermal rigidity.