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Protamine Ratio

Meaning

The stoichiometric ratio of protamine, a small, arginine-rich protein, to insulin within a pharmaceutical formulation, which is a critical determinant of the insulin preparation’s pharmacokinetic profile. This ratio specifically governs the dissolution rate of the insulin-protamine crystal complex after subcutaneous injection, thereby dictating the onset and duration of the hormone’s action. It is a key factor in formulating intermediate-acting insulin preparations.