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Prostate Saturation Model

Meaning

The Prostate Saturation Model describes a physiological concept suggesting that the proliferative effects of androgens, such as testosterone and its metabolite dihydrotestosterone (DHT), on the prostate gland become limited once the androgen receptor population within the target tissue reaches a state of maximal occupancy or “saturation.” Beyond this saturation point, increasing systemic androgen levels yields diminishing returns in terms of prostatic growth or function. This model is crucial for understanding the efficacy limits of androgen replacement or suppression therapies in managing prostatic conditions. It defines the point of receptor saturation.