What is the Origin of Prostate Cell Growth?

This biological term combines "prostate," derived from the Greek prostates (one who stands before), with the fundamental biological process of "cell growth." The endocrine control of the prostate has been recognized since the mid-20th century, linking androgens like dihydrotestosterone (DHT) to prostatic development and pathology. Clinical interventions often target this growth pathway.

What is the Mechanism of Prostate Cell Growth?

Androgens, particularly the potent metabolite dihydrotestosterone (DHT), bind to the androgen receptor within prostate cells, acting as the primary mitogenic signal to stimulate gene transcription that promotes cell survival and proliferation. The enzyme 5-alpha reductase catalyzes the conversion of testosterone to DHT, making it a critical control point. Excessive or prolonged androgen signaling drives the pathological mechanism of hyperplastic or neoplastic prostate cell growth.

Prostate Cell Growth

Meaning

The process of cellular proliferation and increase in mass within the epithelial and stromal tissues of the male prostate gland, a process highly regulated by androgens. While normal growth is necessary for prostate maintenance, dysregulated or excessive proliferation leads to clinical conditions such as benign prostatic hyperplasia (BPH) or prostate cancer. Understanding the hormonal drivers of this growth is central to men’s health and endocrinology.