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Prostate Cancer Saturation Model

Meaning

The Prostate Cancer Saturation Model is a clinical hypothesis regarding the relationship between circulating androgen levels, specifically testosterone, and the growth rate of established prostate cancer cells. This model posits that prostate cancer cell growth is maximally stimulated at a relatively low concentration of androgens, a point referred to as the saturation level. Once the serum androgen concentration exceeds this saturation point, further increases in testosterone do not result in a greater rate of cancer cell proliferation. This framework has significant implications for the safety and design of testosterone replacement therapy in men with a history of prostate cancer.