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PROP1 Gene

Meaning

The PROP1 Gene, also known as Prophet of Pit-1 gene, encodes a crucial transcription factor that is absolutely essential for the proper embryonic development and subsequent maturation of the anterior pituitary gland. This gene dictates the differentiation and proliferation of specific pituitary cell lineages, notably those responsible for producing growth hormone, prolactin, and thyroid-stimulating hormone. A pathogenic mutation in the PROP1 gene is recognized as the most frequent single-gene cause of combined pituitary hormone deficiency, resulting in a severe and widespread spectrum of congenital endocrine insufficiencies that manifest early in life.