Prolactin Suppression Techniques are clinical or lifestyle interventions designed to intentionally lower circulating levels of the hormone prolactin, often when they are pathologically or sub-clinically elevated. While prolactin is primarily associated with lactation, excess levels in men and non-lactating women can negatively impact libido, fertility, and mood, often by interfering with the hypothalamic-pituitary-gonadal (HPG) axis. Suppression is a targeted strategy to restore optimal hormonal balance.
Origin
This concept is rooted in classical endocrinology and the clinical management of hyperprolactinemia, a condition first studied in the mid-20th century. “Prolactin” is derived from its role in promoting lactation, and “Suppression Techniques” refer to the pharmacological or natural methods used to inhibit its release from the anterior pituitary gland.
Mechanism
Prolactin secretion is tonically inhibited by dopamine, a neurotransmitter produced in the hypothalamus. Therefore, suppression techniques primarily involve the use of dopamine agonists, which bind to and activate dopamine receptors on lactotroph cells in the pituitary, thereby inhibiting prolactin release. Certain nutrients or plant compounds can also indirectly enhance dopaminergic tone, serving as non-pharmacological methods to achieve the desired suppression.
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