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Prolactin Sparing Secretagogues

Meaning

Prolactin sparing secretagogues are a specialized class of Growth Hormone Secretagogues (GHS) that are designed to stimulate the release of endogenous Growth Hormone (GH) while exhibiting minimal or negligible effect on the co-secretion of the hormone prolactin. Prolactin elevation is an undesirable side effect of some older GHS compounds, as high levels can lead to sexual dysfunction and pituitary dysregulation. The ‘sparing’ feature is a key pharmacological refinement, ensuring the therapeutic benefits of GH enhancement are achieved without compromising the integrity of the endocrine axes.