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Progestogen Challenge Test

Meaning

The Progestogen Challenge Test is a standard clinical diagnostic procedure utilized in reproductive endocrinology to systematically evaluate the underlying cause of secondary amenorrhea, which is the absence of menstruation in a woman who previously had regular cycles. The test involves administering a short course of a progestogen medication and subsequently observing whether withdrawal bleeding occurs upon its cessation. The resulting pattern of bleeding helps the clinician determine if the amenorrhea is due to a lack of estrogen priming, anovulation, or a structural issue with the uterine outflow tract.