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Progestin Sensitivity

Meaning

Progestin sensitivity describes the degree to which a patient’s tissues, particularly the endometrium, breast, and central nervous system, respond to the biological effects of synthetic progestational compounds, known as progestins. This sensitivity is determined by the concentration and type of progesterone receptors within the target cells, as well as the specific pharmacological properties of the progestin used. Clinical variability in this sensitivity accounts for differences in therapeutic efficacy and the manifestation of side effects during hormone therapy. Understanding this is crucial for personalized hormonal treatment.