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Progestin Selection

Meaning

Progestin selection is the highly nuanced clinical decision-making process of choosing a specific synthetic progestogen, or progestin, from the diverse range of available compounds for use in hormonal therapy or contraception. This choice is critical because various progestins possess distinct pharmacological profiles, including varying degrees of intrinsic androgenic, anti-androgenic, or glucocorticoid activity, which profoundly influence clinical outcomes and the patient’s side effect experience. The final selection must be meticulously personalized based on the patient’s co-morbidities and specific therapeutic goals.