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Progestin Metabolic Effects

Meaning

Progestin metabolic effects refer to the diverse influences that synthetic progestogens, commonly incorporated into hormone replacement therapy and contraceptive formulations, exert on systemic metabolic markers, including plasma lipid profiles, carbohydrate metabolism, and overall insulin sensitivity. These effects are highly variable and fundamentally dependent on the specific progestin’s unique chemical structure and its cross-reactivity with other steroid hormone receptors, such as androgen or glucocorticoid receptors. Careful, informed selection of the specific progestin agent is necessary to minimize potentially undesirable metabolic consequences and preserve cardiovascular health.