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Progestin-Induced Metabolic Shift

Meaning

Progestin-induced metabolic shift describes the measurable alterations in a woman’s carbohydrate, lipid, and protein metabolism that occur following the administration of exogenous progestin hormones, commonly found in hormonal contraceptives or hormone replacement therapy. These shifts can include changes in insulin sensitivity, glucose tolerance, and circulating lipoprotein profiles, representing a critical consideration in the clinical selection of hormonal agents, particularly for individuals with pre-existing metabolic risk factors. The magnitude of the shift is often dependent on the specific progestin type and dosage.