Progesterone Status is the clinical evaluation of circulating levels of the hormone progesterone, alongside an assessment of its functional impact on target tissues, including the endometrium and the central nervous system. This status reflects its role in preparing tissues for potential pregnancy and modulating estrogenic effects. It is a key indicator of luteal phase health.
Origin
This metric is foundational to reproductive endocrinology and gynecology, historically measured to confirm ovulation and luteal adequacy. In broader wellness, its status informs our understanding of mood stability and sleep architecture. We assess its overall contribution to hormonal balance.
Mechanism
Progesterone acts via nuclear receptors to induce specific gene expression patterns, often exerting an inhibitory effect on estrogen-driven proliferation. Furthermore, its neurosteroid metabolite, allopregnanolone, directly enhances GABA-A receptor function, providing anxiolytic and sedative effects that stabilize neural excitability.
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