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Progesterone Signaling Balance

Meaning

The clinical objective of maintaining the optimal concentration ratio and dynamic interaction between progesterone and its primary physiological antagonists, such as estrogen and cortisol, within target tissues. Achieving this balance is crucial for regulating mood, promoting neuroprotection, maintaining bone density, and supporting the integrity of the hypothalamic-pituitary-gonadal (HPG) axis. Dysregulation of this signaling balance is a common feature of perimenopause and chronic stress states.