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Progesterone Sensitivity

Meaning

Progesterone Sensitivity refers to the degree to which a patient’s target tissues and central nervous system respond to the hormone progesterone, determined by the density and functional state of their progesterone receptors. This sensitivity is highly individualized and can be influenced by genetic factors, co-existing hormonal levels, and chronic inflammation. Clinically, variations in progesterone sensitivity explain why some individuals experience profound effects from minimal doses, while others require higher concentrations for therapeutic benefit or experience adverse symptoms despite normal circulating levels. It is a crucial factor in personalizing hormone replacement therapy.