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Progesterone Receptor Variants

Meaning

Progesterone Receptor Variants refer to the different molecular forms of the intracellular protein receptor to which the hormone progesterone binds, including the two main isoforms, Progesterone Receptor A (PR-A) and Progesterone Receptor B (PR-B). These variants are produced from a single gene via alternative translation initiation sites and possess distinct functional roles and tissue-specific expression patterns. The relative ratio and activity of these variants are critical determinants of a target cell’s response to progesterone, influencing conditions like endometriosis and breast cancer risk.