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Progesterone Receptor Upregulation

Meaning

Progesterone receptor upregulation is a fundamental molecular event where the number or intrinsic sensitivity of progesterone receptors (PR) on target cells increases, thereby enhancing the cell’s responsiveness to circulating progesterone. This process is a crucial element of hormonal crosstalk, most notably driven by the preceding presence of estrogen, which effectively primes tissues for subsequent progesterone action. Clinically, this phenomenon is deliberately leveraged to maximize the therapeutic efficacy of administered progesterone.