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Progesterone Receptor Status

Meaning

Progesterone Receptor Status is a critical clinical marker, typically determined via immunohistochemistry on tissue samples, that indicates the presence, concentration, and relative ratio of progesterone receptors (PR-A and PR-B isoforms) within a specific cell population, most commonly in breast or uterine tissue. This status is absolutely critical for predicting a target tissue’s responsiveness to both endogenous and exogenous progesterone and for guiding essential therapeutic decisions, particularly in hormone-sensitive conditions. A positive status signifies a direct, functional pathway for therapeutic progesterone signaling.