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Progesterone Receptor Genotype

Meaning

Progesterone receptor genotype refers to the specific inherited genetic sequence, including any functional polymorphisms or single nucleotide polymorphisms (SNPs), within the gene that codes for the progesterone receptor (PGR). The PGR is a nuclear receptor that mediates the biological effects of progesterone in target tissues, playing a crucial role in reproductive health, neuroprotection, and bone metabolism. Variations in the PGR gene can alter the receptor’s expression level, its binding affinity for progesterone, or the efficiency of its downstream transcriptional activation. This genotype is a key determinant of an individual’s sensitivity and response to both endogenous progesterone and exogenous progestin therapies.