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Progesterone Receptor Affinity

Meaning

Progesterone Receptor Affinity is the quantitative measure of the strength and specificity with which progesterone, or a synthetic progestin, binds to its cognate intracellular receptor protein. This affinity dictates the magnitude of the biological response elicited by the hormone in target tissues, such as the uterus, breast, and central nervous system. A higher affinity means the hormone can exert a greater effect at a lower concentration, making it a critical metric in selecting the appropriate therapeutic agent for hormone replacement. Understanding this metric is essential for achieving precise clinical outcomes while minimizing off-target effects.