What is the Origin of Progesterone Recalibration?

The concept stems from the recognition of progesterone's vital role in the menstrual cycle and its neuroprotective and anxiolytic properties, independent of its reproductive function. The term "recalibration" highlights the precision required in modern hormonal therapy to achieve functional balance, moving beyond simple replacement to fine-tune the dosage and delivery route. This precision is essential for maximizing therapeutic benefit while minimizing potential side effects.

What is the Mechanism of Progesterone Recalibration?

Recalibration typically involves the administration of bioidentical progesterone, often transdermally or orally, in a dose and schedule designed to mimic natural luteal phase levels or to provide continuous endometrial protection. Progesterone acts by binding to its nuclear receptors, influencing gene expression in target tissues like the endometrium and brain. Its key mechanism involves opposing estrogen's proliferative effects and enhancing GABAergic neurotransmission in the central nervous system, which contributes to its calming and sleep-promoting properties, thereby restoring systemic hormonal harmony.

Progesterone Recalibration

Meaning

Progesterone recalibration is a clinical term describing the process of systematically adjusting or re-establishing optimal physiological levels and rhythmic patterns of progesterone, particularly in the context of hormonal imbalance or therapeutic intervention. This is often necessary in perimenopause or in women with conditions like Estrogen Dominance, where progesterone production is diminished or erratic. The goal is to restore the hormone’s critical balancing effects on estrogen, supporting uterine health, sleep quality, and mood stability.