What is the Origin of Progesterone Pellet Therapy?

This method is rooted in the development of controlled-release drug delivery systems within pharmaceutical technology and has been adopted by clinical endocrinology for hormone optimization. The concept of pellet implantation dates back to early hormone research, offering a mechanism to bypass the rapid hepatic metabolism associated with oral administration. The use of bioidentical hormones in this format is a modern refinement.

What is the Mechanism of Progesterone Pellet Therapy?

Following minor surgical insertion into the subcutaneous fat, the progesterone pellet dissolves slowly and predictably through a process of passive diffusion and capillary absorption into the bloodstream. This sustained, non-oral delivery avoids the high peak and trough concentrations seen with daily dosing and prevents the rapid first-pass metabolism in the liver. The

Progesterone Pellet Therapy ∞ Area

Progesterone Pellet Therapy

Meaning

Progesterone Pellet Therapy is a method of hormone replacement that involves the subcutaneous insertion of small, solid pellets composed of bioidentical progesterone, designed to deliver a sustained and consistent release of the hormone into the systemic circulation. This long-acting delivery system is an alternative to daily oral or transdermal administration, aiming to maintain stable, physiological progesterone concentrations over a period of several months. Clinically, this approach is utilized to address symptoms of progesterone deficiency and to provide necessary uterine protection when estrogen is also administered. The stability of the release profile is a key therapeutic advantage.