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Progesterone Neurosteroid Action

Meaning

The rapid, non-genomic influence of the hormone progesterone and its key metabolites, such as allopregnanolone, directly on neuronal function and central nervous system activity, independent of traditional nuclear receptor-mediated effects. In this capacity, progesterone acts as a neurosteroid, modulating neurotransmitter receptor function to exert significant effects on mood, anxiety, sleep architecture, and cognitive function. This distinct action highlights progesterone’s critical role in neurological health beyond its reproductive functions.