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Progesterone Metabolism Genotypes

Meaning

Progesterone Metabolism Genotypes describe the genetic variations, primarily Single Nucleotide Polymorphisms (SNPs), that influence the efficiency of the enzymes responsible for the breakdown and clearance of the steroid hormone progesterone and its active metabolites. These genotypes dictate an individual’s rate of progesterone inactivation, which directly impacts the circulating levels of key neurosteroids like allopregnanolone and the overall balance with estrogen. Clinical assessment of these variants is essential for personalizing progesterone replacement therapy and managing symptoms related to progesterone deficiency or excess.