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Progesterone Equilibrium

Meaning

Progesterone Equilibrium refers to the state of balanced and appropriately timed progesterone concentration relative to other sex steroids, particularly estrogen, throughout the menstrual cycle in females or as a critical neurosteroid in both sexes. In women, this equilibrium is essential for endometrial health, mood stabilization, and successful reproductive function, necessitating a robust luteal phase rise. In all individuals, progesterone metabolites contribute significantly to central nervous system function, influencing sleep quality and anxiety levels. Disruption of this equilibrium, often presenting as relative estrogen dominance, can lead to significant clinical symptoms.