What is the Origin of Progesterone Dosing Schedules?

This concept originates from clinical endocrinology and pharmacology, particularly in the context of Hormone Replacement Therapy (HRT) and the management of reproductive cycles. The schedules were developed based on the physiological role of progesterone, which is secreted cyclically in the pre-menopausal luteal phase, and the need to mitigate the proliferative effects of estrogen on the endometrium.

What is the Mechanism of Progesterone Dosing Schedules?

The mechanism of action is dependent on the schedule: continuous dosing maintains a steady state for systemic and neuroendocrine effects, while cyclical dosing mimics the natural menstrual cycle to induce a withdrawal bleed, protecting the uterine lining. Progesterone exerts its primary therapeutic effect by binding to progesterone receptors, influencing gene expression in target tissues like the endometrium and modulating GABA-A receptors in the brain for anxiolytic and sleep-promoting effects. The selected schedule ensures the therapeutic mechanism aligns with the patient's clinical needs.

Progesterone Dosing Schedules ∞ Area

Progesterone Dosing Schedules

Meaning

Progesterone Dosing Schedules delineate the various clinical regimens for administering progesterone, a key neurosteroid and female reproductive hormone, within hormonal optimization protocols. These schedules range from continuous daily dosing to cyclical administration for a specified number of days per month, each designed to achieve specific therapeutic goals, such as endometrial protection, sleep enhancement, or anxiety modulation. The choice of schedule is highly individualized and dependent on the patient’s menopausal status and concomitant estrogen use.

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HRTioOctober 22, 2025

Progesterone Dosing Schedules

Meaning

Origin

Mechanism

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