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Progesterone Delivery Methods

Meaning

Progesterone Delivery Methods refer to the various pharmaceutical and non-pharmaceutical routes by which the hormone progesterone is introduced into the systemic circulation to achieve therapeutic concentrations. These methods are designed to overcome the challenge of progesterone’s extensive first-pass metabolism when taken orally, ensuring sufficient bioavailability to target tissues like the endometrium, breast, and brain. Common methods include oral micronized capsules, transdermal creams or gels, vaginal suppositories, and intramuscular injections, each offering distinct pharmacokinetic profiles and clinical advantages. The choice of method significantly impacts the hormone’s biological effect and patient adherence.