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Progesterone Cycling Fidelity

Meaning

The physiological accuracy and consistency of the cyclical rise and fall of progesterone during the luteal phase of the menstrual cycle, reflecting optimal corpus luteum function and hypothalamic-pituitary-ovarian (HPO) axis health. Fidelity is crucial for endometrial health, mood stability, and reproductive potential, ensuring the correct hormonal milieu for the second half of the cycle. A loss of fidelity, such as a shortened luteal phase or inadequate peak levels, is a common clinical issue.