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Progesterone Bioavailability

Meaning

Progesterone Bioavailability refers to the fraction of administered progesterone that reaches the systemic circulation and is thus available to exert its biological effects on target tissues throughout the body. This metric is a critical determinant of therapeutic efficacy in hormone replacement therapy and fertility treatments. Progesterone, when administered orally, typically exhibits very low bioavailability due to extensive first-pass metabolism in the liver, necessitating alternative routes of delivery to achieve sufficient therapeutic concentrations. Optimizing bioavailability is a primary goal in formulating effective progesterone treatments, ensuring that the intended dose translates into the desired physiological action.