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Progesterone Absorption

Meaning

Progesterone Absorption is the process by which administered progesterone enters the systemic circulation from its site of administration, determining its bioavailability and therapeutic efficacy. The route of administration profoundly affects the absorption profile; oral micronized progesterone undergoes significant first-pass hepatic metabolism, leading to lower systemic levels of the parent hormone and a high concentration of its sedative metabolites. Transdermal or vaginal routes bypass this initial hepatic processing, resulting in more predictable and higher circulating levels of the parent progesterone. Optimizing progesterone absorption is crucial for achieving the desired clinical outcomes in hormone replacement therapy.