What is the Origin of Probiotics for Hormones?

This concept is a modern extension of traditional probiotic use, driven by the discovery of the estrobolome, the collection of gut bacteria and their genes capable of metabolizing estrogens. The practice is rooted in the understanding that the gut microbiota is a metabolically active endocrine organ. The term synthesizes the long-standing clinical practice of probiotic supplementation with emerging research on the gut's profound influence on hormonal health.

What is the Mechanism of Probiotics for Hormones?

The primary mechanism involves the gut bacteria producing the enzyme beta-glucuronidase, which deconjugates hormones like estrogen that have been prepared for excretion by the liver. Deconjugation reactivates the estrogen, allowing it to be reabsorbed into the bloodstream rather than eliminated via the feces. Probiotics, particularly strains of Lactobacillus and Bifidobacterium, can help modulate the estrobolome to reduce excessive beta-glucuronidase activity, thereby promoting the healthy excretion of excess hormones and supporting hormonal equilibrium.

Probiotics for Hormones

Meaning

Probiotics for Hormones refers to the therapeutic use of live microorganisms, typically bacteria and yeasts, administered to modulate the gut microbiome with the specific goal of influencing systemic hormonal balance and metabolism. This intervention targets the gut-hormone axis, particularly the estrobolome, to promote the healthy circulation and elimination of key sex and metabolic hormones. A balanced microbial environment is considered essential for optimal endocrine function.