A forward-looking clinical discipline focused on identifying, mitigating, and reversing early-stage risk factors for neurodegenerative diseases and cognitive decline before symptoms manifest. This approach integrates advanced neurological assessments with metabolic, hormonal, and genetic data to create personalized prevention and optimization strategies. It represents a paradigm shift from reactive disease management to anticipatory brain health maintenance.
Origin
This emerging field synthesizes traditional neurology with functional medicine and longevity science, driven by the realization that most neurodegenerative diseases have a long preclinical phase amenable to intervention. The term ‘proactive’ emphasizes the shift to early risk identification and aggressive lifestyle and pharmacological modulation. It acknowledges the brain’s profound connection to systemic health, particularly the endocrine system.
Mechanism
Proactive neurology utilizes biomarkers for inflammation, insulin resistance, and hormonal imbalances, such as thyroid and sex steroid deficiencies, which are known risk factors for cognitive decline. Interventions include optimizing metabolic health to support cerebral glucose metabolism, balancing neurotransmitters, and employing neuroprotective strategies like targeted supplementation and cognitive training. The goal is to maintain synaptic plasticity and support the neuroendocrine axes that govern brain function and resilience.
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