Proactive healthspan management is a clinical and lifestyle philosophy centered on intentionally extending the period of life spent in good health, vitality, and functional capacity, rather than merely extending lifespan. This approach emphasizes early and continuous intervention based on individualized biological and physiological assessments, targeting the fundamental mechanisms of aging, such as cellular senescence and metabolic dysfunction. It integrates advanced diagnostics, personalized nutrition, hormonal optimization, and targeted longevity therapeutics. The goal is to compress morbidity and maximize the years lived free from chronic disease.
Origin
The term combines “proactive,” signifying anticipation and preparation, with “healthspan,” a concept that emerged from gerontology and longevity research to distinguish healthy years from total years lived. “Management” denotes the systematic control and guidance of this process. This framework originates in the convergence of preventive medicine, endocrinology, and the science of aging, reflecting a shift toward precision health.
Mechanism
The mechanism involves systematically addressing the nine hallmarks of aging, including genomic instability, telomere attrition, and loss of proteostasis, through evidence-based interventions. Hormonal optimization plays a crucial role by restoring youthful endocrine signaling, which supports mitochondrial function, immune surveillance, and cellular repair pathways. Lifestyle modifications and targeted supplements act to modulate key metabolic sensors, such as mTOR and AMPK, promoting cellular resilience and adaptive stress responses, thereby slowing the rate of biological aging.
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