A Proactive Aging Strategy is a comprehensive, forward-looking plan designed to decelerate the biological aging process by targeting cellular damage accumulation and maintaining youthful endocrine function. This strategy prioritizes the optimization of anabolic signaling relative to catabolic signaling throughout the lifespan. We implement interventions now to ensure higher quality of life in later years, focusing on preserving tissue integrity.
Origin
This term is derived from preventative medicine and geroprotection research, emphasizing intervention before significant functional decline occurs. “Proactive” highlights the shift from reactive disease management to preemptive biological maintenance.
Mechanism
The strategy often involves modulating nutrient sensing pathways, such as transiently suppressing mTOR signaling through time-restricted feeding to induce autophagy and cellular cleanup. Furthermore, maintaining optimal levels of growth hormone and testosterone supports the structural integrity of muscle and bone, key physiological systems that determine functional longevity. Controlling chronic systemic inflammation is another critical mechanism, as inflammation accelerates telomere shortening and cellular senescence.
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