Pro-Senescence Therapy is a therapeutic strategy that deliberately promotes the transition of damaged or stressed cells into a state of irreversible cellular senescence, often as a precursor to their targeted elimination by the immune system or senolytic agents. This approach is clinically relevant when dealing with pre-cancerous cells or cells that have accumulated excessive damage and are actively contributing to chronic inflammation and tissue dysfunction. The goal is to contain the damage and prepare the cell for clearance, thereby reducing the overall burden of dysfunctional cells in a tissue.
Origin
This term is derived from cellular biology and oncology, specifically contrasting with the more common anti-senescence or senolytic approaches. It acknowledges that senescence, while often viewed negatively, can be a protective mechanism that prevents damaged cells from proliferating.
Mechanism
The therapy works by activating key senescence-inducing pathways, such as p53 and p16, in specific cell populations. This activation halts the cell cycle and induces the Senescence-Associated Secretory Phenotype (SASP), which releases signals that attract immune cells for phagocytosis. By forcing a damaged cell into a non-proliferative, signaling state, the therapy effectively prevents tumor formation or pathological tissue remodeling before senolytic agents are applied for complete removal.
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