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Pro-Senescence Therapy

Meaning

Pro-Senescence Therapy is a therapeutic strategy that deliberately promotes the transition of damaged or stressed cells into a state of irreversible cellular senescence, often as a precursor to their targeted elimination by the immune system or senolytic agents. This approach is clinically relevant when dealing with pre-cancerous cells or cells that have accumulated excessive damage and are actively contributing to chronic inflammation and tissue dysfunction. The goal is to contain the damage and prepare the cell for clearance, thereby reducing the overall burden of dysfunctional cells in a tissue.