What is the Origin of Pro-Opiomelanocortin Signaling?

POMC was first identified as a large precursor protein for various pituitary hormones. Its central role in appetite regulation was established when it was discovered that its cleavage product, α-MSH, acts on melanocortin receptors in the brain to inhibit feeding. The name itself reflects its multiple active peptides, including opiate-like compounds and melanocyte-stimulating hormones.

What is the Mechanism of Pro-Opiomelanocortin Signaling?

The POMC neurons in the arcuate nucleus are activated by circulating satiety hormones such as leptin, insulin, and GLP-1. Upon activation, they release α-MSH, which binds to the melanocortin-4 receptor (MC4

Pro-Opiomelanocortin Signaling ∞ Area

Pro-Opiomelanocortin Signaling

Meaning

Pro-Opiomelanocortin (POMC) signaling refers to the crucial anorexigenic, or appetite-suppressing, pathway originating from a specific set of neurons in the hypothalamus. POMC is a precursor polypeptide that is cleaved into several potent neuropeptides, most notably alpha-melanocyte-stimulating hormone (α-MSH). This signaling cascade is the final common pathway for most satiety signals, acting as the body’s brake on food intake. Robust POMC signaling is essential for terminating meals and maintaining long-term body weight homeostasis.