Pro-aging signal reduction is a therapeutic or lifestyle strategy aimed at diminishing the intensity or prevalence of endogenous biochemical signals that actively drive the aging process. These signals often include chronic low-grade inflammation, elevated senescent cell-secreted factors (SASP), and excessive activation of nutrient-sensing pathways like mTOR. By actively reducing these deleterious signals, the goal is to slow the rate of biological decline, promote cellular repair, and extend healthspan. This is a central tenet of modern longevity medicine and hormonal health.
Origin
The term is a conceptual composite derived from “pro-aging signal,” which refers to the molecular drivers of senescence, and “reduction,” meaning to decrease or lessen. It originates from the field of geroscience, which seeks to understand aging as a treatable condition by targeting its fundamental molecular and cellular mechanisms. The concept shifts focus from treating age-related diseases individually to addressing the underlying causes of aging itself.
Mechanism
Strategies for reduction often involve modulating key metabolic and inflammatory pathways. For example, intermittent fasting or specific compounds can transiently inhibit mTOR, promoting cellular cleanup via autophagy, a key anti-aging mechanism. Additionally, managing chronic stress and optimizing the gut microbiome can reduce systemic inflammation and the burden of SASP factors. The ultimate mechanism is the restoration of cellular resilience and the promotion of reparative processes over degenerative ones.
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