What is the Origin of Preservative-Free Hormones?

The demand for these formulations arose from clinical observations of patient sensitivities to various inactive ingredients in standard commercial drug preparations. The concept is linked to the compounding pharmacy practice, which allows for the customization of drug composition to exclude specific allergens or preservatives. The term directly communicates the formulation's composition to the patient and prescriber.

What is the Mechanism of Preservative-Free Hormones?

Preservative-free hormones exert their effect through the standard endocrine mechanism of the active hormone, such as binding to the nuclear receptor to modulate gene transcription. The distinction lies in the delivery vehicle, which is composed only of the necessary base and solvent. The mechanism ensures that the therapeutic action is solely due to the hormone itself, avoiding potential non-specific effects or localized irritation that preservatives might cause at the site of administration.

Preservative-Free Hormones ∞ Area

Preservative-Free Hormones

Meaning

Pharmaceutical hormone preparations, typically compounded or specialized formulations, that contain the active hormone ingredient but exclude common antimicrobial agents or chemical stabilizers like parabens, benzyl alcohol, or other preservatives. These formulations are often preferred for patients with known sensitivities, allergies, or those who wish to minimize exposure to non-essential chemical excipients. The absence of preservatives necessitates careful handling and often results in a shorter shelf life for the medication. This focus on purity is a key element of certain personalized hormone therapies.