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Premature Ovarian Insufficiency Sequelae

Meaning

Premature Ovarian Insufficiency Sequelae describes the collection of long-term adverse health outcomes that result from the early cessation of ovarian function, clinically occurring before the age of 40. The sequelae are directly attributable to the prolonged duration of estrogen and progesterone deficiency, placing these women at a significantly higher lifetime risk for chronic diseases compared to those experiencing typical-age menopause. This critical clinical state requires early, comprehensive hormonal and preventative care to mitigate future risk.