What is the Origin of Pregnenolone Therapy?

Pregnenolone's role was established in the foundational studies of steroid biochemistry, where it was identified as the first steroid synthesized from cholesterol within the mitochondria. The therapeutic application emerged from research into its neuroprotective and mood-enhancing properties, particularly in the context of aging and chronic stress. Its clinical use emphasizes its central position in the hormonal hierarchy.

What is the Mechanism of Pregnenolone Therapy?

The mechanism of action is two-fold: direct neurosteroid effects and downstream hormonal conversion. Pregnenolone acts directly on receptors in the brain, modulating GABA and NMDA receptor activity, which supports memory and reduces anxiety. More broadly, it serves as the substrate for the production of all other steroid hormones in the adrenal glands and gonads. By optimizing pregnenolone levels, the body is provided with the necessary raw material to self-regulate the production of its downstream hormonal metabolites according to physiological demand.

Pregnenolone Therapy

Meaning

Pregnenolone Therapy is the clinical administration of pregnenolone, a crucial neurosteroid and the master precursor hormone in the steroidogenesis cascade, to address age-related decline or specific hormonal deficiencies. As a prohormone, it can be converted into DHEA, progesterone, cortisol, testosterone, and estrogens, making its management a high-level regulatory strategy. This therapy is often employed to support cognitive function, mood stability, and adrenal health.